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Contraindicated (one)pentobarbital will lessen the extent or effect of elbasvir/grazoprevir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the level or effect of ibuprofen by influencing hepatic enzyme CYP2C9/10 metabolism. Small/Importance Unidentified.pentobarbital will decrease the extent or result of fentan